Office Relocation Mount Vernon New York | Cereba Law Blog

Posted by admin on November 29, 2012

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Source: http://www.cerebalaw.com/office-relocation-mount-vernon-new-york-2/

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High Profile UK VC Stefan Glaenzer Faces Jail After Sexual Assault Conviction

The London tech startup scene has been rocked today by revelations that a major investor is facing jail after being convicted of sexually harassing women on the London Underground Tube network. Multi-millionaire Stefan Glaenzer, the former chairman of music streaming site Last.fm and co-founder of the highly active Passion Capital VC fund and the tech cluster of White Bear Yard in Clerkenwell, was said to be under the heavy influence of cannabis at the time, a court heard. German-born Glaenzer, 51 - a former dance DJ for 15 years prior to co-founding Ricardo.de - admitted in court that he had "smoked drugs for some considerable time" and that at the time of the incident he was "on a drugs binge" but that his behaviour had never previously lead to "anything like this."

Source: http://feedproxy.google.com/~r/Techcrunch/~3/3ATw-ZiV67Y/

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60-Million-Year Debate on Grand Canyon?s Age

Richard Perry/The New York Times

New research suggests that the Grand Canyon is about 70 million years old, but the prevailing view is that it is much younger.

How old is the Grand Canyon? Old enough to be gazed on by dinosaurs, which died out 65 million years ago, or closer to six million years old, formed about when the earliest human ancestors began walking upright?

A bitter controversy among geologists over this question edged into the open on Thursday, when a report published in the journal Science offered new support for the old-canyon hypothesis, which is not the prevailing one. In the report, Rebecca M. Flowers of the University of Colorado and Kenneth A. Farley of the California Institute of Technology used an improved dating technique based on the radioactive decay of uranium and thorium atoms into helium atoms in a mineral known as apatite. They said this yielded a thermal record of these rocks under the canyon floor, hot at great depths but cooler the closer they were to the surface.

An analysis of the data, the geologists said, revealed where surface erosion had gouged out canyons and how much time had passed since there was significant natural excavation in the Grand Canyon region. They concluded in the report that the western segment of the canyon was carved to within a few hundred yards of modern depths by about 70 million years ago.

The more ancient origin would put much of the canyon in place in the last epoch of the dinosaurs. Publicity for the journal report duly noted that one of nature?s wonders, dinosaurs, might well have stood and gawked at another wonder, one of today?s most majestic tourist attractions.

This was only one of the immediate objections to the findings raised by geologists favoring the young-canyon school of thought. They said that the research results had been hyped. One critic, Karl E. Karlstrom of the University of New Mexico, noted that the early-canyon model had been proposed before and was ?now in what I think will be a short-lived revival.?

If the interpretation of the findings proves to be correct, it contradicts the prevailing hypothesis that the entire canyon was formed as recently as five million to six million years ago, advocated by many of the notable authorities on Grand Canyon geology. These dates were drawn from an examination of pebbles and other sediments from upstream reaches of the Colorado River system that washed up at the western exit of the canyon.

Dr. Flowers said that when she started this research seven years ago, she had not expected to find the canyon?s presumed age to be so ancient. But the first set of experiments with the radioactive helium technique in 2008 was followed up with a new round of tests and more sophisticated levels of analysis.

In their paper, Dr. Flowers and Dr. Farley wrote that their findings implied a dichotomy in the late eastern and early western canyon origins. This history, they said, ?supports a model in which much of Grand Canyon incision was accomplished by an ancient Cretaceous river that flowed eastward from western highlands,? not from northeast to west, as today?s Colorado River does. This was followed by a ?reversal of the river?s course as topography rose in the east and collapsed in the west,? in consequence of the rising Rocky Mountains.

Dr. Flowers said in an interview that the findings supported the ancient-origin hypothesis advanced in recent years by Brian P. Wernicke, a Caltech geologist, who had proposed such a chain of events. It is still not clear when the eastern and western canyons merged into the canyon as it is seen today.

She also said she foresaw ?a fair amount of controversy? over the research results. That turned out to be an understatement, even before the official publication date.

Dr. Karlstrom of the University of New Mexico is a leader among geologists who have devoted much of their careers to Grand Canyon studies. When reporters called this week, he was prepared with four pages of criticism of the new research. He pointed out that at a meeting two years ago of the most active Grand Canyon researchers, ?a near consensus view was expressed? in support of the young-canyon hypothesis.

As a rule of thumb, he defined the Grand Canyon as ?the canyon you see from the rim today.? How fragments of paleocanyons and paleorivers contributed to the Grand Canyon?s origin is not established, he said.

Dr. Karlstrom was not entirely negative in his assessment of the research. He praised the thermochronology method the researchers used, saying it ?offers one of the few ways we may be able to reconstruct past landscapes in rocks that have long since been eroded away.? The Flowers-Farley team, he added, ?is pushing welcome new advances? in this dating technology.

?Less welcome to me,? he continued, ?is their attempt to push the interpretation of their new data to their limits without consideration of the whole range of other geologic data sets.?

This article has been revised to reflect the following correction:

Correction: November 29, 2012

An earlier version of this article misstated the direction in which the Colorado River flows. It flows from northeast to west, not from west to northeast.

Source: http://www.nytimes.com/2012/11/30/science/earth/study-sees-older-grand-canyon-stirring-controversy.html?partner=rss&emc=rss

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Photos: Monster storm raging on Saturn

DEAR ABBY: My wife and I have been married for five years. I recently discovered that she made between 10 and 20 porn videos when she was 19. We got married when she was 27. We have four kids from two previous marriages.I am devastated. When I confronted her about it, she cried harder than I had ever seen. She said she was lost, and it's the biggest regret of her entire life.I understand how hard it can be to tell someone you have done something like this. I haven't led a perfect life either, and I have my own skeletons and things that I would never mention. But still, I can't get over this. ...

Source: http://news.yahoo.com/photos/nasa-s-cassini-slideshow/

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British Skylon Engine Passes Its Tests

An anonymous reader writes "The BBC reports that the SABRE hybrid (part air-breathing jet, part rocket) that is intended to power the Skylon single-stage-to-orbit space plane has passed its final technical demonstration test, and is now looking for money (only ?250m!) to prepare for manufacturing. If this goes ahead, travel into orbit from local airports (ideally, those close to the equator) will be possible. And quite cheaply. But might it have the same legal difficulties flying from U.S. airports as the Concorde did?"

Source: http://rss.slashdot.org/~r/Slashdot/slashdotScience/~3/s17OIogMpWM/story01.htm

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Poll suggests easy re-election for New Jersey Governor Christie

NEW YORK (Reuters) - Two-thirds of New Jersey voters say Chris Christie deserves to be re-elected next year, and the Republican governor would trounce Newark's Democratic Mayor Cory Booker in a hypothetical match-up, a poll found on Wednesday.

Christie's popularity has soared due to his response to Superstorm Sandy, which slammed the Jersey Shore on October 29, tearing up boardwalks and leaving homes in ruins. On Monday, he filed papers stating an intention to seek re-election.

Christie, whose blunt style has helped make him a Republican star, appeared to set aside politics. He toured the damage with Democratic President Barack Obama days before the November 6 presidential election and showed a personal touch with residents who lost their homes or loved ones in the storm.

Asked if Christie deserved to be re-elected, 67 percent of respondents said yes versus 25 percent who said no, according to the poll conducted by Quinnipiac University.

"Remember, we have a state election in 2013 and the only Democrat who shows any oomph against ... Christie, the hero of Hurricane Sandy, is Newark Mayor Cory Booker. Even he trails the Republican governor by double digits," said Quinnipiac poll director Maurice Carroll.

Like Christie, Booker is a charismatic politician who has cultivated a place on the national political stage in part thanks to an aggressive use of social media. The two men have made much of their close working relationship.

According to the poll, Christie would beat Booker by a margin of 53 percent to 35 percent. Just over half of voters have a positive view of Booker, but about a third say they do not know enough about him to form an opinion.

Still, with the election 11 months away, Democrats have cautioned Christie's popularity may subside.

"I appreciate, and I think the residents of our state appreciate, his leadership. But once we get through the crisis, I think people are going to start thinking of other things," said State Senator Loretta Weinberg, a Democrat who said she was hopeful Booker would enter the race.

The survey of 1,664 registered voters was conducted from November 19 to 25 and had a margin of error of plus or minus 2.4 percentage points, Quinnipiac said.

(Editing by Daniel Trotta and Cynthia Osterman)

Source: http://news.yahoo.com/poll-suggests-easy-election-jersey-governor-christie-110329805.html

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Scientists identify depression and anxiety biomarker in youths

ScienceDaily (Nov. 28, 2012) ? Scientists have discovered a cognitive biomarker -- a biological indicator of a disease -- for young adolescents who are at high risk of developing depression and anxiety. Their findings were published today, 28 November, in the journal PLOS ONE.

The test for the unique cognitive biomarker, which can be done on a computer, could be used as an inexpensive tool to screen adolescents for common emotional mental illnesses. As the cognitive biomarker may appear prior to the symptoms of depression and anxiety, early intervention (which has proven to be one of the most effective ways of combatting mental illness) could then be initiated.

For the study, 15-18 year old participants underwent genetic testing and environmental assessment, an exercise which would currently be too expensive and take too long to use as a widespread method of screening. The adolescents were then given a computer test to gauge how they process emotional information. The test had the participants evaluate whether words were positive, negative or neutral (examples included 'joyful' for positive, 'failure' for negative, and 'range' for neutral).

Those adolescents with a variation of one gene (the short form of the serotonin transporter) as well as exposure to intermittent family arguments for longer than six months and violence between parents before the age of six were shown to have marked difficulty in evaluating the emotion within the words, indicating an inability to process emotional information. Previous research associated a maladjusted perception and response to emotions, as seen here, with a significantly increased risk of depression and anxiety.

Professor Ian Goodyer, Principal Investigator on the study from the University of Cambridge, said: "Whether we succumb to anxiety and depression depends in part on our tendencies to think well or poorly of ourselves at troubled times. How it comes about that some people see the 'glass half full' and think positively whereas other see the 'glass half empty' and think negatively about themselves at times of stress is not known.

"The evidence is that both our genes and our early childhood experiences contribute to such personal thinking styles. Before there are any clinical symptoms of depression or anxiety, this test reveals a deficient ability to efficiently and effectively perceive emotion processes in some teenagers -- a biomarker for low resilience which may lead to mental illnesses."

The scientists hope that their research could lead to developing inexpensive cognitive tests to screen for these illnesses, particularly in people identified as being at high social and genetic risk.

Dr Matthew Owens from the University of Cambridge added: "Having difficulty in processing emotions is likely to contribute to misunderstanding other people's intentions and can make individuals emotionally vulnerable. This research opens up the possibility of identifying individuals at greatest risk and helping them with techniques to process emotions more easily or training them to respond more adaptively to negative feedback."

Professor Goodyer further stated: "These types of cognitive biomarker can also be used to aid therapeutics by helping to determine which treatments are likely to work best for types of depressions and anxiety disorders. This is important, as although we have good treatments we do not yet know what works best for whom."

Professor Barbara Sahakian, a co-author on the paper from the Department of Psychiatry at the University of Cambridge said: "The way we perceive and respond to emotions affects our resilience and whether we succumb to depression and other maladaptive ways of thinking. Using the biomarker identified in this study, it is possible to develop a screening programme to identify those at greatest risk."

Mental health problems are common in young people with approximately 10% of children (aged 5-16 years old) in Great Britain being assessed as having a mental disorder of some kind including conduct disorder, emotional disorder or hyperactivity. In addition, adolescence is a critical period for the development of depressions.

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The above story is reprinted from materials provided by University of Cambridge. The original article is licensed under a Creative Commons Licence.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Matthew Owens, Ian M. Goodyer, Paul Wilkinson, Anupam Bhardwaj, Rosemary Abbott, Tim Croudace, Valerie Dunn, Peter B. Jones, Nicholas D. Walsh, Maria Ban, Barbara J. Sahakian. 5-HTTLPR and Early Childhood Adversities Moderate Cognitive and Emotional Processing in Adolescence. PLoS ONE, 2012; 7 (11): e48482 DOI: 10.1371/journal.pone.0048482

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/XxfsDCw3PXM/121128182949.htm

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Latin American VOD service Totalmovie partners with Sony, unveils live TV and carrier billing plans

Latin American VOD platform?Totalmovie is planning to venture into live online content early next year, Mexican newspaper El Economista reports.

The company also unveiled a partnership with Sony, which will start offering a Totalmovie app across its devices, including connected TVs, Blu-ray players, tablets and cell phones ? presumably in the Latin American territories where the service is available.

Carrier billing is also in the plans across the region, as users will be able to pay for Totalmovie?s content on their mobile bill. In Mexico, Totalmovie will now offer this option through mobile operator Iusacell, in order to reach the many Mexicans who don?t have a credit card.

As you may know, Totalmovie?s parent company belongs to Mexican media group Grupo Salinas, which also owns media giant TV Azteca and above-mentioned carrier Iusacell.

According to El Economista, sources close to the group revealed that Totalmovie?s live content will initially originate from TV Azteca, which owns Mexico?s second largest TV channel. As for Totalmovie, it currently boasts 1.9 million subscribers.

These announcements were made by Grupo Salinas? President and CEO, Ricardo Salinas Pliego, during an official launch event. ?Totalmovie will be the world?s first live online TV service,? he said.

Competition is stirring up in Latin America?s online video sector, where the growing list of over-the-top players includes Netflix, but also Bazuca, Claro Video and Walmart-owned movie streaming service Vudu.

In addition to these services, Totalmovie?s live TV offering would also help it compete against the online TV properties of Mexican billionaire Carlos Slim, such as Uno TV in Mexico and Ora TV in the US.

Image credit: NICOLAS ASFOURI / AFP / Getty Images

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Source: http://thenextweb.com/la/2012/11/27/latin-american-vod-service-totalmovie-partners-with-sony-unveils-live-tv-and-carrier-billing-plans/

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Obama, Boehner optimistic on fiscal cliff (Reuters)

Share With Friends: | | Politics - Top Stories News, RSS Feeds and Widgets via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/266999333?client_source=feed&format=rss

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Pharmacy Technician Jobs - references and education directory ...

Regardless of how our economic situation fares, the pharmacy technician career will have an easier time staying afloat and the demand for it will only continue to grow. Pharmacy technician jobs are teeming all over the place, but the heavy competition may make things had for you. So if you want to find yourself being sought after by an employer, receiving proper training and certification is necessary.

You don?t really have to undergo formal training in order to become a pharmacy technician, but there are additional benefits if you do. Educational institutions such as vocational schools, community colleges, and hospitals offer formal training programs ranging from a 6 months to 24 months. If you want to be qualified for the best pharmacy technician jobs, getting formal education is recommended.

Once you have completed you formal training program, you can make yourself even more attractive to potential employers by working hard to attain certification and other credentials. Certification is an excellent indication of your competency as a pharmacy tech. You can seek to become certified by either the Pharmacy Technician Certification Board (PTCB) or the Institute for the Certification of Pharmacy Technicians (PTCB).

If you try to notice the requirements among the majority of pharmacy technician jobs, they require applicants to have reliable communications and interpersonal skills since they will be spending most of their time working with healthcare workers and interacting with patients. Sound mathematical and analytical skills are also a must when preparing medications.

Pharmaceutical firms are not the only places where pharmacy technician jobs can be found ? there are also plenty of employment opportunities in hospitals, convenience stores, and department stores which have their own pharmacy. To help make your search easier, you can take advantage of the internet and you can also submit your resume to online job directory websites.

The classified ads section of your local newspaper can also give you plenty of options when it comes to pharmacy technician jobs. If you have decided that you want to apply for a job in a pharmaceutical firm, you may want to drop by the company website to check out their employment opportunities and know more about what they are looking for.

If you think getting a diploma from a pharmacy tech school is very difficult, well think again. Check out our website about pharmacy technician certification and we?ll provide you with materials to help you reach your dreams. Visit www.pharmacytechnicianreviews.org now.

Source: http://referencesandeducation.info/2012/11/pharmacy-technician-jobs-how-to-deserve-a-higher-pay/

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Students at cooperative schools are more engaged

ScienceDaily (Nov. 26, 2012) ? Student engagement is not independent of the type of school attended. Nor is it independent of the organisational development of the school. The school's organisational style affects the work of its teaching staff, which, in turn, has repercussions on the performance and engagement of their students. As Iker Ros, the UPV/EHU researcher, has been able to verify in his PhD thesis, these factors vary when comparing public schools, subsidised schools and co-operative schools, the latter being the ones that fare best.

"The study of engagement is a subject that motivates me a lot, because I believe that a student who is engaged with his or her school is also engaged with his or her environment," says Iker Ros. As a PhD holder in Psychopedagogy, he has analysed the differences in the organisational development of schools by looking at their typology and the level of engagement of their students, and highlights that the best results were achieved at the associated work co-operative school in Vitoria-Gasteiz (Basque Country).

The study was carried out with students from primary and secondary school. The thesis is entitled "Desarrolloorganizacional de unacooperativa de trabajoasociado y la Implicaci?n de sus estudiantes y docentes" (Organisational Development of an associated work cooperative and the Engagement of its students and teaching staff) and some of his conclusions have been published recently in the Revista de Psicodid?ctica.

The greater the organisational development, the more engagement there is

According to the results, organisational development is higher in a co-operative than in subsidised schools, and public schools come between the two. "We have established highly significant statistical differences," explains Ros; "you have to bear in mind that the associated work co-operative is much more horizontal. In schools of this kind people collaborate more, and this leads to greater organisational learning. They are organisations that learn."

As far as the students are concerned, it has also been the students at a co-operative school who have displayed the greatest engagement, while those of the public schools are the most hostile. "If the biggest difference in the engagement of the workers is to be found between the co-operative and the subsidised schools, the same thing does not happen with respect to the students. The biggest difference emerges between the co-operative and the public schools, which indicates to us that work clearly needs to be done with the students attending public schools which, despite having a more similar organisational development, have less engagement," reflects Ros.

This engagement is made up of three elements: the emotional or psychological aspect, translated into the feeling of belonging to the school; the behavioural element, which is extracted from the data on student participation in teaching and extramural activities; and the cognitive element that has to do with the students' perception of academic work and future expectations. "It is a subject that is of great educational importance in the Anglo-Saxon sphere and in China and Taiwan as well," stresses the author, "but studies on the subject have not yet been published here."

Ros has also detected differences with respect to the sex and age of the students. For example, engagement is greater among girls than among boys, and in both cases falls with age, above all at secondary school and sixth form levels.

In this study the author also wanted to check whether the teaching staff is the factor that most influences the students, as established by previous pieces of research. On the basis of the hypothesis that the greater the organisational development is, the greater and better the work of the teaching staff is, and consequently the greater student engagement is, Ros believes that the results leave no room for doubt. "The results seem to indicate that, in actual fact, the work of the teacher and his/her engagement would need to be better considered, but this is being undermined today at a time of cutbacks," he stresses. In this respect, Ros foresees an increase in the number of associated work co-operative schools due primarily to two factors: firstly, the economic crisis, and the fall in the number of members of religious orders who are putting the management of their schools into the hands of teachers through co-operative formulas.

The research was carried out at 14 public (10) and subsidised (4) schools in the Basque Country and Catalonia -- in collaboration with the Autonomous University of Barcelona -- ; and at an associated work co-operative school in Vitoria-Gasteiz. A total of 1,273 students between 9 and 17, and 343 teachers participated in the study.

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The above story is reprinted from materials provided by Basque Research.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Iker Ros, Javier Goikoetxea, Joaqu?n Gair?n, Pablo Lekue. Student Engagement in the School: Interpersonal and Inter-Center Differences // Implicaci?n del alumnado en la escuela: diferencias interindividuales e intercentros. Revista de Psicodidactica / Journal of Psychodidactics, 2012; DOI: 10.1387/RevPsicodidact.4557

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/M3AyDIHJssM/121126142951.htm

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Serbia seeks evidence against freed Croat generals

BELGRADE, Serbia (AP) ? Serbia asked U.N. war crimes prosecutors on Monday to hand over evidence against two Croatian generals whose convictions have been overturned, reigniting tensions between the Balkan wartime rival states.

Ante Gotovina and Mladen Markac were released this month by a U.N. war crimes court in The Hague, Netherlands, after it overturned their convictions for involvement in violence that drove thousands of Serbs from their homes and left hundreds dead during a 1995 Croatian military offensive known as Operation Storm.

In an unusual step, the Hague tribunal's chief prosecutor, Serge Brammertz, said at the time that his office was disappointed by the 3-2 ruling by the appeals judges.

On Monday, Serbia's war crimes prosecutors said they have asked U.N. prosecutors to hand over the evidence used during the trial of the two generals so they can consider whether to indict them in Serbia.

Gotovina and Markac are considered heroes in Croatia for their role in the 1991-95 war for independence from Serb-led Yugoslavia. Serbia has said it has opened its own investigation of war crimes committed during the offensive.

Croatian officials say they also will investigate the events, but not the two generals, who received state honors and a hero's welcome after being freed from detention.

Brammertz said recently that "evidence collected by my office will remain available to judicial authorities in the former Yugoslavia to facilitate national prosecutions for the crimes committed in connection with Operation Storm."

But legal experts say a retrial in Serbia or The Hague would only be possible if prosecutors find some dramatic new war crimes evidence against the two generals.

The U.N. judgment sparked fury in Serbia, where many see the tribunal as biased against them because the majority of the war criminals it has convicted have been Serbs.

Croatians viewed the acquittals of Gotovina and Markac as support for their claim that their nation was a victim in the Balkan wars.

Croatian President Ivo Josipovic said Serbia should not take out its anger at the U.N. court ruling on Croatia.

"The fact is that it is not Croatia that freed the generals, but that the highest legal authorities in The Hague decided that our generals are not guilty," Josipovic told Croatian state HRT television. "It's a matter of respect toward the international community and international law."

However, Serbian nationalist President Tomislav Nikolic reiterated that the judgment does not help reconciliation and jeopardizes his dialogue with Josipovic.

"It's not going well with Croatia," Nikolic told Belgrade daily Kurir. "He wants us to talk ? me as the president of a nation which has committed crimes, and him as the president of a nation which has not been convicted of anything."

"Croatians know that the crime committed during the Storm is awful, but they still celebrate because no one was convicted," Nikolic said. "They are a nation on a wrong path."

Despite the Serb anger, more than 6,000 Croats have joined a Facebook page in support of Gotovina ? a former French Foreign Legion soldier ? becoming the next Croatian president. The 57-year-old general has said he has no intention of pursuing a political career.

___

Mike Corder contributed from the Netherlands.

Source: http://news.yahoo.com/serbia-seeks-evidence-against-freed-croat-generals-163703962.html

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Health and Fitness Talk ? Lactose Intolerance

by Kimberly Allen, R.N.

Lactose intolerance also known as?lactase deficiency?is a condition in which you are unable to absorb lactose, the primary sugar in milk and dairy products.? Lactose intolerance is actually very common in adults with approximately 30 million American adults having some degree of lactose intolerance by the time they?re 20 years of age.? Lactose usually affects Caucasian children over 5 years of age, while it frequently develops in African Americans as early as 2 years of age.
In a normal healthy intestine there are cells on the villi that live the in the small intestine that produce an enzyme known as lactase.? The lactose molecule is a large sugar molecule that is composed of 2 smaller sugars glucose and galactose.? Lactose must first be divided into the 2 separate sugars before the body can absorb it.? Lactase is the enzyme needed to perform that task.? There are three things that can cause a deficiency in lactase.? It can be either congenital, developmental or secondary.? Congenital lactose deficiency is caused by a mutation in the gene responsible for the production of lactase.? Secondary lactase deficiency is caused by a disease that deteriorates the villi lining te small intestine.? The most common cause of lactase deficiency is developmental.? This type usually develops after childhood when milk is no longer the primary source of nutrition and the production of lactase decreases as you grow and your diet becomes more varied and not as dependent on milk.? People that drink minimal to no milk as they get older will produce less and less lactose leading to symptoms of lactose intolerance.? The rate at which the production of lactose decreases is genetically programmed therefore the prevalence of this type of lactose deficiency is highly variable among different? ethnic groups.? For example in Asian populations it is nearly 100% and in Native American population it is approximately 80% while the prevalence in African Americans is around 70% and in Caucasian Americans the rate is around 20%.
Most people will notice symptoms with in 30 minutes to 2 hours after consuming lactose.? The most commonly experienced symptoms include diarrhea, nausea and vomiting as well as bloating, abdominal cramps and gas.? Symptoms of lactose intolerance can range from mild to severe.
There is no cure for lactose intolerance.? Treatment is aimed at reducing the amount of lactose in your diet.? Most people with lactose intolerance are able to tolerate small to moderate amounts of lactose so frequently it only takes eliminating only those products that contain large amounts of lactose like milk, cottage cheese, yogurt and ice cream.? Some people are able to tolerate yogurt because yogurt is made with bacteria that contain lactase.? There are numerous substitutes for milk available today including soy and rice milk.? It is also important to avoid any prepared foods that contain milk as well as any dishes that have any cream sauces in restaurants.? There are also lactase tablets and caplets available that you can take with foods containing milk.? Eliminating dairy products can lead to calcium deficiency so it?s important to include other foods that are high in calcium like broccoli, spinach, oranges, and rhubarb as well as canned salmon to name a few.
If you have lactose intolerance become a smart shopper.? Always read food labels carefully looking for milk as well as other ingredients like milk by-products, curds and whey as well as non fat dry milk powder and milk solids, all of these contain lactose.? It is also important to be aware that certain prescription as well as over the counter medications use lactose as a base including certain birth control pills
If you are having difficulty adjusting your diet your Dr may recommend a dietician to assist you.

Kimberly Allen is a registered nurse with an AND in nursing. She has worked in ACF, LCF and psychiatric facilities, although she spent most of her career as a home health expert. She is now a regular contributor to HealthAndFitnessTalk.com, dispensing advice and knowledge about medical issues and questions. You can reach her with any comments or questions at? mussatti3@gmail.com.

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Source: http://www.healthandfitnesstalk.com/lactose-intolerance/

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Price and buyer trends lead to upswing in Johor Bahru condo market

Cheyenne Hollis | Nov 26, 2012 | Comments 0

The condo market in Johor Bahru has grown in recent times as demand from buyers has increased.

The rapid development of condominiums and apartments in Johor Bahru is based upon the increase in land prices and changing trends of buyers in the region, the Malaysia Chronicle reported.

Chairman of Real Estate and Housing Developers? Association (Rehda) Johor Branch, Koh Moo Hing said the young generation is now more interested to live in condominiums and apartments due to trend and security factors.

?Property buyers, particularly amongst the young generation now choose the gated and guarded concept such as condominiums and apartments as they place more importance on the security factor,? Koh said.

He added property development companies in Johor Bahru were not really interested to build condominiums and apartments in the past and use to focus on terraced houses and bungalows.

The scenario has changed over the last few years with developers racing to build condominiums and apartments in this city following high demand from buyers, Koh said.

SP Setia Bhd launched a 55-storey high-end condominium, the tallest in Iskandar Malaysia, known as Sky 88, which is expected for completion within four years, the newspaper reported.

Other developers following suit include Kumpulan JoLand?s ne development the Paragon Residences@Straits View comprising 32-storey and Dijaya?s Tropez Residences at Danga Bay.

Both Paragon Residences and Tropez Residences are fronting the Johor Straits, which is very popular amongst the foreign buyers. Locations considered as hot spots include Danga Bay, Nusajaya and Medini.

According to the Johor Bahru City Council and Johor Bahru Tengah Municipal Council, there are more than 25,000 condominium and apartment units in the city that are under construction or in the process of getting building approvals.

Filed Under: Country News ? Malaysia ? News

Tags: buyer trends ? condo market ? johor bahru ? Malaysia ? new developments johor bahru

Source: http://www.property-report.com/price-and-buyer-trends-lead-to-upswing-in-johor-bahru-condo-market-26089

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Web Of Trust, The Crowdsourced Safe Surfing Tool, Raises Further $1.3M Led By Inventure

Web of Trust (WOT), the safe surfing tool/browser add-on which is powered by the crowd, has raised a fresh ?1M (approx. ~$1.3M) led by Finland/China-based VC firm, Inventure. Also participating in the round is private investor, Risto Siilasmaa, and Finnish Industry Investment, a previous backer of the Helsinki-based company. The new capital will be used for "additional product development" as WOT aims to continue on a growth path that has seen it double the number of downloads for its browser add-on over the last year, to total 50 million.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/LE6j-xSEwnQ/

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What I Learned This Week in ActiveRain- November 18- November ...

I Learn Something New at ActiveRain Every Day and It's Time I Showed You. ?November 18 - November 24, 2012.

I learn something new every day at ActiveRain! ?With this series I try to highlight one post per day that gave me that ?lightbulb? moment. ?It could be something techie, about Real Estate, about a place or person!

November 18: ??Pat Kennedy ???How Can You Best Respond to Comments on Your Post.
I?d been feeling guilty because while I?ve tried to respond to each comment I received in a timely manner, I sometimes can?t. ?I feel very guilty about it but after reading Pat?s post, I?ve decided not to beat myself up so much. ?I?m still trying, though to respond to each comment. ?

November 19: ?Bill & Liz Spear ????The Wrong Floor Plan is Like Thanksgiving Without Turkey
I?ve seen ?spacious? 2400 Sq Ft homes and 4000+Sq Ft homes that lacked useful liveable space. ?If you?re selling or buying a home, square footage isn?t everything... look at its liveability.

November 20: ?Ken Tracy ???Live Life with Open Doors.
Ken does a great job of showing us just how being open to life, whatever may come, can be a better way then living your life behind closed doors.

November 21: ?Reuben Saltzman ??Illegal Plumbing Products in Minnesota
So many homeowners fancy themselves DIY owners but Reuben shows us that just because it?s sold at Home Depot or any other hardware store doesn?t necessarily mean you can or should use it.

November 22: Melissa Zavala ???Healthy Turkey : Check It Out.
Not everyone likes turkey or eats meat. ?This is something you could do for fun!!! And, you could get the kiddies involved!

November 23: ??Sharon Tara ??Holiday Stress? ?The Way You Breathe Could Be Causing Anxiety.

Funny little thing about breathing... you need to do it. ??As in yoga breathing Sharon shows us how to make sure our breathing isn?t causing our anxiety.

November 24: ??Gary Woltal ??Choosing Kindness As Your Life?s Reflection.
What are we putting out there in the world? ??It is how we want others to view us? ?Read Gary?s post....bet you?ve met people like this.

Thank you for letting me do what I love to do each day... learn something new!

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Source: http://activerain.com/blogsview/3530273/what-i-learned-this-week-in-activerain-november-18-november-24-2012

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Massachusetts natural gas explosion damages 42 buildings

SPRINGFIELD, Mass. (AP) ? Preliminary investigations show more than 40 buildings were damaged in a natural gas explosion in Massachusetts that injured 18 people, building inspectors said Saturday.

A strip club was flattened and a day care center was heavily damaged in the massive blast Friday night in Springfield, one of New England's biggest cities.

Investigators were trying Saturday to figure out what caused the blast that could be heard for miles, left a large hole in the ground where the multistory brick building housing Scores Gentleman's Club once stood and scattered debris over several blocks.

Officials already had evacuated part of the entertainment district after responding to a gas leak and odor reported about an hour before the explosion. Gas workers venting a gas leak got indications that the building was about to explode and they ducked for cover behind a utility truck ? along with firefighters and police officers ? just before the blast, said Mark McDonald, president of the New England Gas Workers Association.

Most of the injured were in that group, and the truck that saved their lives was essentially demolished, he said.

"It really is a miracle and it's an example of our public safety officials, each and every day, putting themselves in harm's way, taking what could have been considered a very routine call of an odor of gas, but they took the proper precautions," State Fire Marshal Stephen Coan said. "And thanks to God that they did."

Officials also marveled how the 5:30 p.m. blast occurred when a day care center next door was closed. The center's building was heavily damaged.

Lt. Gov. Tim Murray and Springfield Mayor Domenic Sarno were attending a tree-lighting ceremony when the explosion occurred. Sarno said some people mistakenly thought the boom was part of the holiday event.

The explosion blew out windows in a three-block radius, leaving at least three buildings irreparably damaged and causing emergency workers to evacuate a six-story apartment building that was buckling, police said. Pieces of broken glass littered streets and sidewalks. It was unclear how many residents had been evacuated. A shelter was set up at a school, but city officials said no one stayed there overnight.

Omar Fermin, manager of the Punta Cana Restaurant two blocks from the explosion site, found the floor-to-ceiling windows blasted out when he came to check on the property Saturday morning.

"It looks like an earthquake hit," said Fermin, a native of the Dominican Republic. "I've never seen anything like it."

He said he was waiting for someone to come and assess the damage. He worried the restaurant would remain closed for weeks while the owner seeks to replace the massive custom-made windows.

Authorities cordoned off the center of the explosion Saturday as building inspectors worked to identify unsafe structures. Anxious residents gathered at the perimeter, waiting for permission to visit their buildings.

Preliminary reports show the blast damaged 42 buildings housing 115 residential units, said Thomas Walsh, spokesman for the mayor.

Three buildings were immediately condemned, and 24 others require additional inspections by structural engineers to determine whether they are safe, Walsh said.

Dogs trapped in abandoned buildings barked loudly Saturday as building inspectors fanned out across the area. One inspector said he wished he could get a ladder and permission to retrieve a dog that was barking in the upper floor of one building sealed off from residents.

Authorities are opening an animal shelter for pets affected by the explosion, Walsh said.

Coan, the fire marshal, said his office is investigating the cause of the blast and its possible origin. The state's Department of Public Utilities was also investigating.

Sheila Doiron, a spokeswoman for Columbia Gas of Massachusetts, said the company will continue to monitor for any potential leaks within several blocks of the blast site. So far, she said, the company hadn't yet found any measurable readings.

The utility will keep at least 30 workers at the scene, along with a so-called sniffing car mounted with sophisticated gadgets capable of detecting low levels of gas leaks, Walsh said.

Doiron said the company also didn't find in its records any gas odor calls to the area where the strip club was located.

Authorities also deployed police officers throughout the area to prevent looting, Walsh said.

The victims were taken to two hospitals in the city. Those injured were nine firefighters, two police officers, four Columbia Gas workers, two civilians and another city employee.

Springfield, which is 90 miles west of Boston and has about 150,000 residents, is the largest city in western Massachusetts. It's known as the home of the Basketball Hall of Fame, which is not near the blast site.

The city has been rebuilding from damage caused by a tornado in June 2011.

___

Associated Press writers Rodrique Ngowi, Bridget Murphy and Bob Salsberg in Boston and Jessica Hill in Springfield contributed to this report.

Source: http://news.yahoo.com/mass-natural-gas-explosion-damaged-42-buildings-201318033.html

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Syrian rebels capture air base near Damascus

BEIRUT (AP) ? Syrian rebels captured a helicopter base just outside Damascus Sunday in what an activist called a "blow to the morale of the regime" near President Bashar Assad's seat of power.

The takeover claim showed how rebels are advancing in the area of the capital, though they are badly outgunned, making inroads where Assad's power was once unchallenged. Rebels have also been able to fire mortar rounds into Damascus recently.

The director of the Britain-based Syrian Observatory for Human Rights, Rami Abdul-Rahman, said rebels seized control of the Marj al-Sultan base on the outskirts of Damascus on Sunday morning. He said at least 15 rebels and eight soldiers were killed in the fighting that started a day earlier. The rebels later withdrew from the base.

Rebels appear to be trying to take over air bases and destroy aircraft in order to prevent the regime from using them in attacks against opposition forces around the country.

The rebels have no protection against the attack helicopters and fighter jets that have been blasting their positions.

Rebels have been attacking air bases in different parts of Syria, mostly in the northern regions of Idlib and Aleppo.

In the battle at the base outside Damascus, Abdul-Rahman and Damascus-based activist Maath al-Shami said rebels destroyed two helicopters with rocket propelled grenades and captured a tank. They say the base, which is on the eastern outskirts of Damascus, houses several radar positions.

"This is a blow to the morale of the regime, because it is close to the heart of the capital," said Abdul-Rahman, referring to the base that is about 15 kilometers (10 miles) from Damascus.

Al-Shami said the rebels withdrew from the base after they captured some ammunition. He said they feared counterstrikes by regime aircraft.

An amateur video posted online showed rebels walking next to two destroyed helicopters. At least three other helicopters appeared undamaged. Black smoke billowed in the distance.

Another video showed several radar posts on hills inside the large compound. Parked military trucks stood inside as rebels roamed freely.

The activist videos appeared genuine and corresponded to other AP reporting about the events depicted. Syria restricts the access of reporters.

The Observatory also reported violence in other parts of Syria, including the country's largest city of Aleppo in the north and the capital itself.

It said rebels on Sunday captured a training base for the Popular Front for the Liberation of Palestine-General Command near the Damascus suburb of Douma. The PFLP-GC is one of the Palestinian factions most loyal to Assad.

The PFLP-GC said in a statement late Saturday that the base was under attack. It said that thousands of activists and fighters who fought against Israel were trained at the base over the past 30 years.

Also Sunday, the Observatory said a bomb targeted a bus in the southern village of Othman, killing at least five people and wounding dozens. It said rebels and troops clashed in the southern region of Quneitra on the edge of the Israeli-occupied Golan Heights.

The Local Coordination Committees, another activist group, said residents found 12 bodies in the Damascus suburb of Daraya, scene of heavy clashes between rebels and government troops over the past few days.

State TV said troops clashed with al-Qaida militants in Daraya, killing some of them and confiscating a mortar that they were using in their attacks.

The station said that troops killed an al-Qaida affiliated Palestinian militant known as Abu Suhaib in the Damascus suburb of Hajira. It said his group was behind several bombings in Syria that killed and wounded dozens of people.

Assad's regime blames the revolt on a foreign conspiracy. It accuses Saudi Arabia and Qatar, along with the United States, other Western countries and Turkey, of funding, training and arming the rebels, whom it calls terrorists.

Syria's conflict erupted in March 2011 with an uprising against President Bashar Assad's regime, inspired by other Arab Spring revolts. It quickly morphed into a civil war that has since killed more than 40,000 people, according to activists.

Source: http://news.yahoo.com/syrian-rebels-capture-air-near-damascus-140725464.html

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Feb. 15: Submit to Scotiabank EcoLiving Award : SustainabilityNews

Got a Great Home Energy Efficiency Solution? Submissions for 2013 Scotiabank EcoLiving Awards in Business Leadership, Innovation and Student Leadership Now Open!

With rewards totalling $75,000, Scotiabank today announced the opening of submissions for the Scotiabank EcoLiving Awards, a unique Canada-wide awards program that recognizes businesses, innovators and students for excellence in the development of home energy efficiency products, services and solutions. Submissions can be made through
Scotiabank?s EcoLiving website until February 15, 2013.

Full information on the awards, including submission forms, key dates, eligibility and judging criterion are now available exclusively on Scotiabank?s EcoLiving website.
?The EcoLiving Awards showcase outstanding Canadian home energy efficiency
solutions at all levels ? from students to business leaders ? and we?re
looking forward to another year of high-calibre submissions,? said Kaz
Flinn, Vice President of Corporate Social Responsibility for Scotiabank.
?It?s the only awards program in Canada that recognizes home efficiency
excellence. We?re thrilled to reward innovators and share their
energy-saving ideas with all Canadians.?

The Scotiabank EcoLiving awards are:

.?? ?The Scotiabank EcoLiving Business Leadership Award ($50,000) -? to
be awarded to a business or individual who is leading the way in home energy
efficiency products, services or solutions.

.?? ?The EcoLiving Innovators Award ($15,000) ? will go to a business or
individual who is demonstrating innovation in home energy efficient
products, services and solutions. Where the Business Leadership Award will
focus primarily on the execution of a proven idea or program, the
Innovator?s Award will focus on the introduction of exciting new ideas for
products or programs.

.?? ?The Scotiabank EcoLiving Student Leadership Award ($10,000) ? will
be awarded to a full-time college or university student who demonstrates
promise for the future of home energy conservation.

Full information on the awards, including submission forms, key dates,
eligibility and judging criterion are now available exclusively on
Scotiabank?s EcoLiving website, http://ecoliving.scotiabank.com/awards.

The largest green awards program in Canada, the Scotiabank EcoLiving Awards
were introduced in 2011 and are a cornerstone of the Bank?s broader
EcoLiving Program aimed at enabling and encouraging Canadians to save money
and energy at home.

Winners of the first EcoLiving Awards came from across Canada. BUILD of
Winnipeg, Manitoba won the Scotiabank EcoLiving Business Leadership Award
for its pioneering not-for-profit program of retrofitting low-income
Winnipeg homes with energy saving materials. EcoPlusHome of Bathurst, New
Brunswick, a company that designs and builds prefabricated homes that put
zero demand on the power grid won the Scotiabank EcoLiving Innovators Award.
Eden Full, of Calgary, Alberta, received the Scotiabank EcoLiving Student
Leadership Award for her invention of the SunSaluter, an affordable tracking
rotation system that maximizes the output of solar panels requiring 40 per
cent fewer panels. Learn more about their solutions and progress.

The Scotiabank EcoLiving Program website launched in June, 2010, offering a unique online consumer resource that provides home greening options together with government rebate and financial savings information all in one place ? providing an easy-to-use resource for Canadians to learn about, plan and compare green home improvement options. The website includes project planning tools and a financial calculator to allow visitors to compare products and rebates, plan and finance their projects and see the savings that can result from each energy efficient renovation. The EcoLiving Magazine is available twice yearly in Scotiabank branches and the Scotiabank EcoLiving Awards recognize innovation in residential energy efficiency.

Scotiabank is one of North America?s premier financial institutions and
Canada?s most international bank. With more than 81,000 employees,
Scotiabank and its affiliates serve some 19 million customers in more than
55 countries around the world. Scotiabank offers a broad range of products
and services including personal, commercial, corporate and investment
banking. With assets of $670 billion (as at July 31, 2012), Scotiabank
trades on the Toronto (BNS) and New York Exchanges (BNS). For more
information please visit www.scotiabank.com

Source: https://blogs.dal.ca/sustainabilitynews/2012/11/23/feb-15-submit-to-scotiabank-ecoliving-award/

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SEO - Big Thinking Online

Many businesses realise the hard way after investing in a website that traffic, leads and sales do not magically appear on the internet. Businesses are competing with millions of websites to be seen, and this is where search engine optimisation comes in. It is no longer good enough to just have a website, you need to make sure it can be found through the major search engines and this is why SEO is so important.

A website that is not optimised is as successful at attracting new clients to your business as the sign above your business. It is only visible to those that are standing directly in front of it or who already know your business is there. People in the next street, the next town, the next city will have no idea you even exist.

That?s why SEO needs to be high on your list of imperatives. If you are not continually working on your online presence to boost and maintain your search engine rankings, your company will likely experience a poor return on investment for its online marketing efforts. Without a search engine optimisation strategy, your organisation could be losing countless potential prospects and new business to competitors who are?focusing?on SEO.

While many business owners believe that SEO can be a ?set it and forget it? exercise it is more evident than ever that it requires constant vigilance and adjustment. Major shifts in the area of search have been taking place over the last few years and businesses that don?t adjust will see their listings sink to the bottom of the results pages.

Search Engine Optimisation is still new to many businesses and because of that it can be hard for department heads or business owners to justify investing in SEO. Here are some facts that might help your decision:

Top 10 Reasons Why SEO is Worth the Investment

Close Rate?? According to HubSpot?s 2012 State of Inbound Marketing, SEO leads have a 14.6% close rate, which are 8 times more likely to close into customers than outbound leads.

People Search for a Reason?? Search engines are one of the most popular ways that people find information and make purchasing decisions. According to?info please, 81% of internet users say they use the internet to do research on a product before buying.

Real time, All the time ? The internet is alive and speaking to your potential clients 24/7/365. So while your business is closed and there is no one manning the phone lines a perfectly optimised website can be providing useful and valid information about your products and services, helping them conduct their research and putting you in the prime position when they are ready to buy.

Branding?? SEO helps improve brand awareness. People are more likely to move forward with a company if they have an online presence that fills the searcher with trust. By showing up where users expect you to be and having a great online reputation you can earn that trust.

Relevance ? Search engine marketing enables brands to reach the audience that is most likely to be interested in their products or services. This can be contextually, where results are based on what the searcher is particularly looking for or location based, where your audience is at the moment of time. Both of which add to why SEO is so important for business.

Reach ? According to UKOM in September 2012, over 42 million individuals in the UK where online, that is 69.4% of the total population and on average people spent 25:44hrs online.

Creativity ? Search engine optimisation offers businesses and marketing teams a limitless creative canvas to attract and captivate their target audience through multimedia: video, audio, imagery, text, all of which can be used to drive customer engagement.

Long Term Benefits?? A print advert, a direct mail campaign, a radio advert once delivered is gone and if your target audience miss the advert there is little chance of them finding t again. If you have a website that is optimised for targeted keywords that drive traffic on a daily basis you will have the opportunity to engage potential clients on a day by day basis for years to come.

Competition?? in most cases doing something because everybody else is doing it is not necessarily a strong argument. However if a business is serious about generating? a healthy supply of leads then not being optimised while others in the niche have adopted a local seo strategy, will mean that those leads, prospects and sales will be going straight to those that have made the investment.

Organic ? In a recent report conducted by GroupM carried out with Nielsen, Evaluating the Search Marketing Landscape, it was found that only 6% of clicks were from paid search while a massive 94% were from searches in the organic listings. This in itself highlights why SEO, and having your business listed for key terms related to your business and niche in the organic listings, is so important?for business.

Accountability ? Unique to the internet is the ability to show the entire customer journey: the number of sales, newsletter sign ups, the number of times people click on your listing in the search engines, where they go, what they interact with and much, much more.

All of this information can then be used to work out where to target your efforts to increase conversions.

Although it can be difficult to justify spending money on something that doesn?t yield immediate results and comes with few guarantees, it?s important to realise that SEO is a lasting investment and can be a fundamental part of your lead generation strategy moving forward.

Consumers are using the internet for everything, as the demand for information about products and services continues to increase and the numbers of ways people can access the information evolve, search engine optimisation is not going away. In fact the need is only going to get stronger. So instead of asking why SEO is a good investment, maybe you should be asking yourself why didn?t we invest in SEO sooner?

Source: http://bigthinkingonline.com/why-seo/

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Team solves birth and migration mysteries of cortex's powerful inhibitors, 'chandelier' cells

Team solves birth and migration mysteries of cortex's powerful inhibitors, 'chandelier' cells

Friday, November 23, 2012

The cerebral cortex of the human brain has been called "the crowning achievement of evolution." Ironically, it is so complex that even our greatest minds and most sophisticated science are only now beginning to understand how it organizes itself in early development, and how its many cell types function together as circuits.

A major step toward this great goal in neuroscience has been taken by a team led by Professor Z. Josh Huang, Ph.D., at Cold Spring Harbor Laboratory (CSHL). Today they publish research for the first time revealing the birth timing and embryonic origin of a critical class of inhibitory brain cells called chandelier cells, and tracing the specific paths they take during early development into the cerebral cortex of the mouse brain.

These temporal and spatial sequences are regarded by Huang as genetically programmed aspects of brain development, accounting for aspects of the brain that are likely identical in every member of a given species including humans. Exceptions to these stereotypical patterns include irregularities caused by gene mutations or protein malfunctions, both of which are now being identified in people with developmental disorders and neuropsychiatric illnesses.

Chandelier cells were first noticed only 40 years ago, and in the intervening years frustratingly little has been learned about them, beyond the fact that they "hang" individually among great crowds of excitatory cells in the cortex called pyramidal neurons, and that their relatively short branches make contact with these excitatory cells. Indeed, a single chandelier cell connects, or "synapses," with as many as 500 pyramidal neurons. Noting this, the great biologist Francis Crick decades ago speculated that chandelier cells exerted some kind of "veto" power over the messages being exchanged by the much more numerous excitatory cells in their vicinity.

Born in a previously undiscovered 'country'

After three years of painstaking work that has involved using new technologies to identify and trace neural cell progenitors in ways not previously possible, and to track them as they migrate to positions in the maturing cortex, Huang and colleagues, including Dr. Hiroki Taniguchi now at the Max Planck Florida Institute, have demonstrated that chandelier cells are born in a previously unrecognized portion of the embryonic brain, which they have named the VGZ (ventral germinal zone).

Huang, who has been on a decade-long quest to develop means of learning much more about the cortex's inhibitory cells (sometimes called "interneurons"), points out that while they are far less numerous than the excitatory pyramidal cells all around them, cells including chandelier cells that inhibit or modulate excitatory-cell messages play an indispensable role in balancing message flow and ultimately in determining the functional organization of excitatory neurons into meaningful groups.

This is all the more intriguing in the case of chandelier cells, Huang explains, because of their distinctive anatomy: one cell that can regulate the messages of 500 others in its vicinity is one that we need to know about if we want to understand how brain circuits work. Unlike other inhibitory cells, chandelier cells are known to connect with excitatory cells at one particular anatomical location, of great significance: a place called the axon initial segment (AIS) ? the spot where a "broadcasting" pyramidal cell generates its transmittable message. To be able to interdict 500 "broadcasters" at this point renders a single chandelier cell a very important player in message propagation and coordination within its locality.

Because of the strategic importance of such cells throughout the cortex, it has been a source of frustration to neuroscientists that they (and other inhibitory cells) have been difficult to classify. Huang has pursued a strategy of following them from their places of birth in the emerging cortex.

Many inhibitory cells come from a large incubator area called the MGE (medial ganglionic eminence); until now, it was not known that most chandelier cells are not born there, and indeed do not emerge until after the MGE has disappeared. Only at this point does the much smaller VGZ form, providing a place where neural precursor cells specifically give rise to chandelier cells.

The team learned that manufacture of a protein encoded by a gene called Nkx2.1 is among the signals marking the birth of a chandelier cell. The gene's action, they found, is also necessary to make the cells. Nkx2.1is a transcription factor, whose expression has previously been linked to the birth of other inhibitory neuronal types. Huang's team observes that it is the timing of Nkx2.1's expression in certain precursors -- following disappearance of the MGE and appearance of the VGZ -- that enabled them to track the birth, specifically, of chandelier cells.

Highly specific migration route and cortical destinations

"In addition to being surprised to discover that chandelier cells are born 'late'?after other inhibitory cells ? in a part of the cortex we didn't know about," says Huang, "our second surprise is that once born, these cells take a very stereotyped route into the cortex and assume very specific positions, in three cortical layers." (Layers 2, 5 and 6). "This leads us to postulate that other specific cortical cell types also have specific migration routes in development."

As Huang points out, his team's new discoveries about chandelier cells have implications for disease research, since it is known that the number and connective density of chandelier cells is diminished in schizophrenia. Associations of the same type have recently been made in epilepsy.

"To know the identity of a cell type in the cortex is in effect to know the intrinsic program that distinguishes it from other cell types. In the broadest terms, we are learning about those aspects of the brain development that make us human. 'Nurture,' or experience, also has a very important role in brain development. Our work helps clarify the 'nature' part of the nature/nurture mystery that has always fascinated us," Huang says.

###

"The spatial and temporal origin of chandelier cells in mouse cortex" appears online ahead of print November 22, 2012 in Science Express.

Cold Spring Harbor Laboratory: http://www.cshl.org

Thanks to Cold Spring Harbor Laboratory for this article.

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